Endocrine Abstracts

Osteoprotogerin (OPG) and the receptor activators of nuclear factor-kβ (RANK) and nuclear factor-kβ ligand (RANKL) play an important role in bone metabolism. RANKL binds to RANK, which is expressed by osteoclasts, whereas OPG acts as its decoy receptor, blocking the RANK–RANKL interaction.The aim of our study was to evaluate bone turnover parameters (serum calcium, phosphorus, alkaline phosphatase, parathormone, osteocalcine, 24-...

Thyroid hormones play an important role in bone metabolism. The potential action of prolonged levothyroxine therapy on bone mass reduction is stil a matter of debate.The aim of our one year prospective study was to elucidate whether longterm suppressive thyroid hormone therapy in patient with differentiated thyroid cancer (DTC) affects bone metabolism, osteoprotegerin (OPG) and soluble receptor activator of nuclear factor kβ ligand (sRANK-L) and is ...